All other cells in site is working fine without any issues.
Also there is no step change in Uplink interference too.
Since this counter increased over all user throughput got decreased in the site.
L.Traffic.UL.SCH.QPSK.TB.Retrans - This counter also increased since the same time.
For this you have to analyze % of each qam.
Keep in mind that in UL antenna pattern ( of ue) is very much like omni whereas in DL (of enodeB) is very directive.
So there is much more interference in UL.
Check the counters NI noise and interference to see any change.
Max and avg for UL.
Like those ones:
L.UL.Interference.Avg.PRBx (Average interference and noise received by PRB x in a cell), where x is PRB from 0 to 273.
Like this qpsk/(qpsk+16qam+64qam+256qam).
This way is much better.
And same for 16qam/(qpsk+16qam+64qam+256qam).
And for 64qam/(qpsk+16qam+64qam+256qam).
Put all 4 percentages in a graph and you will have a clearer view of what is going on.
Ok, then quite possible for noise.
Please try for neighbour cell coverage reduction.
Check for ultargetbler parameter,TA samples, any new site integrated in area.
It seems degradation happened gradually between 21/04 - 16/08 and then stabilised.
That is very long period for affect of parameter or physical optimisation (you can see affects literally from hour of change).
Plot number of users on same graph and see the trend. If users are increasing in same time window (21/04 - 16/08) it means more customers are coming up in your area and they are largely in poor RF conditions. You need to improve their RF condition in order to improve performance.